Journal article
A Composite Epigenetic Biomarker of FOXP3/TIGIT Correlates With Regulatory T Cell Numbers in Cord Blood and Is Associated With Subsequent Food Allergy
VH Nguyen, M O'Hely, F Collier, L Sominsky, P Dhar, J Molloy, AL Ponsonby, MLK Tang, P Sly, R Saffery, B Novakovic, P Vuillermin, L Harrison, T Mansell, D Burgner, S Ranganathan
Clinical and Experimental Allergy | Published : 2025
DOI: 10.1111/cea.70172
Abstract
Background: Flow cytometry studies have reported an association between lower regulatory T cells (Treg) in cord blood and subsequent food allergy. Flow cytometry, however, is a resource-intensive technique. We therefore aimed to develop an epigenetic biomarker (nTregepi) that correlates with the proportion of naïve regulatory T cells (nTreg) in cord blood white cells (CBWCs) measured by flow cytometry. We then investigated the association between nTregepi and subsequent food allergy. Methods: The Barwon Infant Study (BIS) is a prebirth cohort study (n = 1074 infants). Illumina Infinium MethylationEPIC v1.0 BeadChips were used to assess DNA methylation in cord whole blood (n = 936). In a subg..
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Grants
Awarded by National Health and Medical Research Council